A major theme is Cloak and Dagger's sometimes strained friendship, and their difficulty in deciding what their roles as heroes should be--protecting the innocent or dealing out retribution to wrongdoers? The two supporting characters introduced in the limited series--Father Delgado and police detective Bridget O'Reilley--receive a couple of pages in each issue, though each is developed in a dark and somewhat surprising direction from their initial portrayal in the limited series: Father Delgado turns from a devoted priest trying to help Cloak and Dagger and save their souls to becoming somewhat of a pervy old man with a thing for Dagger. Meanwhile, O'Reilley goes from a "by the book" cop trying to crack down on police corruption to a cop who tortures crooks for info before being turned into a (literal) monster in the form of a super-powered vigilante named Mayhem. Mantlo is able to expand on Cloak and Dagger's backstory by introducing Dagger's mom (an oblivious, drunken bitch) and her step-father, who wants to be a good dad but Dagger keeps him at a distance.
I'm not sure why the decision was made to launch the book as a bi-monthly, as to my recollection bi-monthly books seemed to inevitably become cancelled as it was hard for fans to want to wait a couple of months to see the next chapter of a story. In any event, Cloak and Dagger would continue to receive a solo feature as one half of the (also short lived) book Strange Tales.